Monsignor Roberto Campisi was born in Siracusa (Italy) on 18 November 1978. He was ordained a priest on 7 December 2002 and is incardinated in the Archdiocese of Siracusa.
He holds a doctorate in Utroque Iure (Canon and Civil Law).
He entered the Diplomatic Service of the Holy See on 1 July 2010 and served in the Pontifical Representations in Côte d’Ivoire, Venezuela and Italy, and subsequently in the Section for General Affairs of the Secretariat of State.
On 26 October 2022, Pope Francis appointed him Assessor for General Affairs of the Secretariat of State.
On 27 September 2025, Pope Leo XIV entrusted him with the office of Permanent Observer of the Holy See to UNESCO.